Tetrahydrofuran → 4-[3-bromo-4-[(4,5-difluoro-2-nitrophenyl)methoxy]-5-ethoxyphenyl]-2-methyl-5-oxo-7-propyl-4,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile

Reaction equation

[Br:14][c:15]1[cH:16][c:17]([CH:25]2[C:26]([C:40]#[N:41])=[C:27]([CH3:39])[NH:28][C:29]3=[C:34]2[C:33](=[O:35])[CH2:32][CH:31]([CH2:36][CH2:37][CH3:38])[CH2:30]3)[cH:18][c:19]([O:22][CH2:23][CH3:24])[c:20]1[OH:21].[CH2:75]1[O:76][CH2:77][CH2:78][CH2:79]1.[F:1][c:2]1[cH:3][c:4]([N+:11](=[O:12])[O-:13])[c:5]([CH2:9][OH:10])[cH:6][c:7]1[F:8].[O:61]=[C:62]([O:63][CH:64]([CH3:65])[CH3:66])[N:67]=[N:68][C:69]([O:70][CH:71]([CH3:72])[CH3:73])=[O:74].[c:42]1([P:43]([c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)[cH:56][cH:57][cH:58][cH:59][cH:60]1>>[F:1][c:2]1[cH:3][c:4]([N+:11](=[O:12])[O-:13])[c:5]([CH2:9][O:10][c:20]2[c:15]([Br:14])[cH:16][c:17]([CH:25]3[C:26]([C:40]#[N:41])=[C:27]([CH3:39])[NH:28][C:29]4=[C:34]3[C:33](=[O:35])[CH2:32][CH:31]([CH2:36][CH2:37][CH3:38])[CH2:30]4)[cH:18][c:19]2[O:22][CH2:23][CH3:24])[cH:6][c:7]1[F:8]