Nitrogen → 12-Hydroxy-N-{2-[(2-hydroxyethyl)amino]ethyl}octadecanamide

A 30-ml two-necked flask equipped with a stirrer and dropping funnel was charged with 2.08 g (20 mmol) of aminoethylaminoethanol and 0.054 g (1 mmol) of sodium methoxide. While heating and stirring the contents at 80° C. in an N2 atmosphere, a solution of 3.29 g (10 mmol) of ethyl 12-hydroxystearate in 10 ml of THF was added dropwise over 2 hours. The resultant mixture was stirred further for 13 hours at 80° C. under reduced pressure. After completion of the reaction, the reaction mixture was poured into 500 ml of water, and precipitate formed was purified by flash column chromatography on silica gel, thereby obtaining 2.85 g (yield: 74%) of the title compound (IIf-1).

1. customA 30-ml two-necked flask equipped with a stirrer
2. temperatureWhile heating
3. customAfter completion of the reaction
4. customformed
5. customwas purified by flash column chromatography on silica gel

ORD record

ord-4e7d6fabfea64e0cb15c31ea61de1db0

Source dataset

uspto-grants-1998_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05723497