Dimethylformamide → 2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-acetamide

HRID 112354

Reaction equation

HRID 112354 reaction equation
[CH3:20][CH2:21][N:22]([CH2:23][CH3:24])[CH2:25][CH3:26].[CH3:62][N:63]([CH3:64])[CH:65]=[O:66].[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][CH:7]2[CH2:8][CH2:9][N:10]([C:13]([C:14](=[O:15])[OH:16])=[O:17])[CH2:11][CH2:12]2)[cH:18][cH:19]1.[NH2:27][c:28]1[cH:29][c:30]2[c:31]([nH:32][c:33](=[O:35])[nH:34]2)[cH:36][cH:37]1.[P-:38]([F:39])([F:40])([F:41])([F:42])([F:43])[F:44].[n:45]1([O:46][C:47]([N:48]([CH3:49])[CH3:50])=[N+:51]([CH3:52])[CH3:53])[c:54]2[cH:55][cH:56][cH:57][cH:58][c:59]2[n:60][n:61]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][CH:7]2[CH2:8][CH2:9][N:10]([C:13]([C:14](=[O:16])[NH:27][c:28]3[cH:29][c:30]4[c:31]([nH:32][c:33](=[O:35])[nH:34]4)[cH:36][cH:37]3)=[O:17])[CH2:11][CH2:12]2)[cH:18][cH:19]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 667655-Amino-2-hydroxybenzimidazoleHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 51342220[4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid

Product 1

HCID 101575702-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-acetamide

Sources & evidence

ORD record
ord-6ffa02c4ffad493db8d0b8c8a2564543
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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