Sodium Ion → Diethyl [(2-methyl-4-phenyl-1,3-oxazol-5-yl)methyl]propanedioate

Reaction equation

[Br:14][CH2:15][c:16]1[c:17](-[c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[n:18][c:19]([CH3:21])[o:20]1.[C:3]([CH2:4][C:5](=[O:6])[O:7][CH2:8][CH3:9])(=[O:10])[O:11][CH2:12][CH3:13].[CH3:28][N:29]([CH3:30])[CH:31]=[O:32].[H-:1].[Na+:2].[OH2:33]>>[C:3]([CH:4]([C:5](=[O:6])[O:7][CH2:8][CH3:9])[CH2:15][c:16]1[c:17](-[c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[n:18][c:19]([CH3:21])[o:20]1)(=[O:10])[O:11][CH2:12][CH3:13]

Participants

Reactant 6

HCID 923Sodium Ion

HCID 962Water

HCID 6228Dimethylformamide

HCID 7761Diethyl Malonate

HCID 166653Hydride

HCID 132932915-Bromomethyl-2-methyl-4-phenyloxazole

Product 1

HCID 13646801Diethyl [(2-methyl-4-phenyl-1,3-oxazol-5-yl)methyl]propanedioate

Sources & evidence

ORD record: ord-e4250f5eedb74d9dad02fe7c1d0487ec
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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