Tetrahydrofuran → 3-[4-chloro-2-(2,4-difluorobenzoyl)amino-6-fluoro-3-methoxyphenyl]-1-methyl-6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedione

HRID 1130384

Reaction equation

HRID 1130384 reaction equation
[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[F:32][c:33]1[c:34]([C:35](=[O:36])[Cl:37])[cH:38][cH:39][c:40]([F:42])[cH:41]1.[NH2:1][c:2]1[c:3](-[n:12]2[c:13](=[O:24])[n:14]([CH3:23])[c:15]([C:19]([F:20])([F:21])[F:22])[cH:16][c:17]2=[O:18])[c:4]([F:11])[cH:5][c:6]([Cl:10])[c:7]1[O:8][CH3:9].[O:43]1[CH2:44][CH2:45][CH2:46][CH2:47]1>>[NH:1]([c:2]1[c:3](-[n:12]2[c:13](=[O:24])[n:14]([CH3:23])[c:15]([C:19]([F:20])([F:21])[F:22])[cH:16][c:17]2=[O:18])[c:4]([F:11])[cH:5][c:6]([Cl:10])[c:7]1[O:8][CH3:9])[C:35]([c:34]1[c:33]([F:32])[cH:41][c:40]([F:42])[cH:39][cH:38]1)=[O:36]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 5880812,4-Difluorobenzoyl chlorideHCID 183145373-(2-Amino-4-chloro-6fluoro-3-methoxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H, 3H)pyrimidinedione

Product 1

HCID 183145403-[4-chloro-2-(2,4-difluorobenzoyl)amino-6-fluoro-3-methoxyphenyl]-1-methyl-6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedione

Sources & evidence

ORD record
ord-41ccd96d84e54cd7ab5545a828f2b3b9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Linked notes

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