Isopropanol → 1-Methyl-4-(1-piperazinyl)-1H-pyrazolo[3,4-d]pyrimidine

Reaction equation

[CH2:23]1[CH2:24][NH:25][CH2:26][CH2:27][NH:28]1.[CH:29]([OH:30])([CH3:31])[CH3:32].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH3:11])[n:9][cH:10]2.[OH:12][c:13]1[n:14][cH:15][n:16][c:17]2[n:18]([CH3:19])[n:20][cH:21][c:22]12>>[c:2]1([N:25]2[CH2:24][CH2:23][NH:28][CH2:27][CH2:26]2)[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH3:11])[n:9][cH:10]2

Participants

Reactant 4

HCID 3776Isopropanol

HCID 4837Piperazine

HCID 2197514-chloro-1-methyl-1H-pyrazolo(3,4-d)pyrimidine

HCID 178481767HCID 178481767, compound

Product 1

HCID 113564151-Methyl-4-(1-piperazinyl)-1H-pyrazolo[3,4-d]pyrimidine

Sources & evidence

ORD record: ord-d5ea4f5d210840399aaeff0be9c74669
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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