Chloride → 6-[p-(2,2-dichlorocyclopropylcarbonylamino)-phenyl]-4,5-dihydro-3(2H)-pyridazinone

Reaction equation

[Cl-:15].[Cl:16][C:17]1([Cl:23])[CH:18]([C:20](=[O:21])[OH:22])[CH2:19]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([C:8]2=[N:13][NH:12][C:11](=[O:14])[CH2:10][CH2:9]2)[cH:6][cH:7]1.[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([C:8]2=[N:13][NH:12][C:11](=[O:14])[CH2:10][CH2:9]2)[cH:6][cH:7]1)[C:20]([CH:18]1[C:17]([Cl:16])([Cl:23])[CH2:19]1)=[O:21]

Participants

Reactant 4

HCID 312Chloride

HCID 8028Tetrahydrofuran

HCID 6767506-(4-Aminophenyl)-4,5-dihydropyridazin-3(2H)-one

HCID 27949752,2-Dichlorocyclopropane-1-carboxylic acid

Product 1

HCID 128073376-[p-(2,2-dichlorocyclopropylcarbonylamino)-phenyl]-4,5-dihydro-3(2H)-pyridazinone

Sources & evidence

ORD record: ord-3d8dac2b0c9e4e22a98a7762c212ce5c
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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