Tetrahydrofuran → 3-(4-bromomethylphenyl)-1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazole

HRID 114657

Reaction equation

HRID 114657 reaction equation
[C:44]([Br:45])([Br:46])([Br:47])[Br:48].[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[F:1][C:2]([O:3][c:4]1[cH:5][cH:6][c:7](-[n:10]2[n:11][c:12](-[c:15]3[cH:16][cH:17][c:18]([CH2:21][OH:22])[cH:19][cH:20]3)[n:13][cH:14]2)[cH:8][cH:9]1)([F:23])[F:24].[c:25]1([P:26]([c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[cH:39][cH:40][cH:41][cH:42][cH:43]1>>[F:1][C:2]([O:3][c:4]1[cH:5][cH:6][c:7](-[n:10]2[n:11][c:12](-[c:15]3[cH:16][cH:17][c:18]([CH2:21][Br:45])[cH:19][cH:20]3)[n:13][cH:14]2)[cH:8][cH:9]1)([F:23])[F:24]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 66776992{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]-phenyl}-methanol

Product 1

HCID 667770563-(4-bromomethylphenyl)-1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazole

Sources & evidence

ORD record
ord-946c4b9bf10b46c5b08113c982aebc31
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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