Tetrahydrofuran → 1-(3,4-Dichlorobenzyl)-3-(4-formylthiazol-2-yl)urea

Reaction equation

[Al+3:26].[Cl:1][c:2]1[cH:3][c:4]([CH2:5][NH:6][C:7]([NH:8][c:9]2[s:10][cH:11][c:12]([C:14](=[O:15])[N:16]([O:17][CH3:18])[CH3:19])[n:13]2)=[O:20])[cH:21][cH:22][c:23]1[Cl:24].[H-:25].[H-:28].[H-:29].[H-:30].[Li+:27].[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1>>[Cl:1][c:2]1[cH:3][c:4]([CH2:5][NH:6][C:7]([NH:8][c:9]2[s:10][cH:11][c:12]([CH:14]=[O:15])[n:13]2)=[O:20])[cH:21][cH:22][c:23]1[Cl:24]

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 28486Lithium ion

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 866612922-(3-(3,4-dichlorobenzyl)ureido)-N-methoxy-N-methylthiazole-4-carboxamide

Product 1

HCID 866227621-(3,4-Dichlorobenzyl)-3-(4-formylthiazol-2-yl)urea

Sources & evidence

ORD record: ord-751683bb42b1454eaece4f563936bccb
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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