Benzenamine, 4-(4-morpholinyl)- → HCID 178418945, compound

HRID 11538

Reaction equation

HRID 11538 reaction equation
O[CH:2]=[C:3]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=3)=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:20].[N:21]1([C:27]2[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH:28]=2)[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>O1CCCC1>[CH3:19][O:18][C:14]1[CH:13]=[C:12]([C:8]2[CH:7]=[C:6]3[C:11]([C:3](=[CH:2][NH:33][C:30]4[CH:29]=[CH:28][C:27]([N:21]5[CH2:22][CH2:23][O:24][CH2:25][CH2:26]5)=[CH:32][CH:31]=4)[C:4](=[O:20])[NH:5]3)=[CH:10][CH:9]=2)[CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 178418992HCID 178418992, compound

Product 1

HCID 178418945HCID 178418945, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by refluxing 0.020 gms E & Z 3-hydroxymethylene-6-(3-methoxy-phenyl)-1,3-dihydro-indol-2-one with 0.020 gms. 4-morpholin-4-yl-phenylamine in tetrahydrofuran (0.33 mL) for 2 days. Following cooling to room temperature, solvent evaporation in vacuo, trituration with isopropanol and filtration the reaction yields the named compound as a solid in the amount of 15.7 mg.

Workup

  1. customThe named compound is prepared
  2. customsolvent evaporation in vacuo, trituration
  3. filtrationwith isopropanol and filtration the reaction

Sources & evidence

ORD record
ord-e83cfed6237146ecaad1c4492e25a9ff
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Linked notes

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