Hydrochloric Acid → HCID 20434988, compound
Reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.C([NH:14][NH:15][C:16]([NH2:18])=[O:17])(=O)C.[ClH:19]>C(O)C>[ClH:19].[NH:15]([C:16]1[O:17][CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:18]=1)[NH2:14]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of α-bromoacetophenone (19.9 g) and acetylsemicarbazide (10.7 g) in ethanol (300 ml), containing 1N hydrochloric acid (1 ml), was refluxed for thirty hours. The solvent was removed in vacuo and the residue was crystallized from ether-ethanol to give 2-hydrazino-4-phenyloxazole hydrochloride. This salt was suspended in an aqueous solution of 10% ammonium hydroxide to give 2-hydrazino-4-phenyloxazole, m.p. 158°-160° C.
Workup
- temperaturewas refluxed for thirty hours
- customThe solvent was removed in vacuo
- customthe residue was crystallized from ether-ethanol
Sources & evidence
- ORD record
- ord-1ded7daa9b324099bb4ce3130b060fb1
- Source dataset
- uspto-grants-1984_12
- Patent number
- US04489084
Reaction notes
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