Propargyl alcohol → 3-(4-(Trifluoromethyl)phenyl)prop-2-yn-1-ol

Reaction equation

[Br:1][c:2]1[cH:3][cH:4][c:5]([C:8]([F:9])([F:10])[F:11])[cH:6][cH:7]1.[CH2:12]([C:13]#[CH:14])[OH:15].[CH2:16]([NH:17][CH2:18][CH3:19])[CH3:20].[Cu:21][I:22]>>[c:2]1([C:14]#[C:13][CH2:12][OH:15])[cH:3][cH:4][c:5]([C:8]([F:9])([F:10])[F:11])[cH:6][cH:7]1

Participants

Reactant 4

HCID 7859Propargyl alcohol

HCID 8021Diethylamine

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

Product 1

HCID 118304283-(4-(Trifluoromethyl)phenyl)prop-2-yn-1-ol

Sources & evidence

ORD record: ord-6de8418a0be74d409f3a31ae8e8c0eb0
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…