Tiopronin → HCID 56608455, compound

HRID 1155144Notes

Reaction equation

HRID 1155144 reaction equation
[SH:1][CH:2]([CH3:10])[C:3]([NH:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4].[C:11]1([C:17]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>FC(F)(F)C(O)=O>[C:17]([S:1][CH:2]([CH3:10])[C:3]([NH:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4])([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 5483TioproninHCID 6457Triphenylcarbinol

Product 1

HCID 56608455HCID 56608455, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

To a solution of alpha-mercaptopropionyl glycine (50 g; 0.307 moles) in 300 ml of trifluoroacetic acid, were added 79.9 g (0.307 moles) of triphenylcarbinol. The thus obtained solution was kept under stirring at room temperature for 15 minutes. The excess of trifluoroacetic acid was removed by evaporation and the residue taken up with ether. Filtration yielded a white solid, which was then washed with ether and dried in vacuo to constant weight.

Workup

  1. customThe excess of trifluoroacetic acid was removed by evaporation
  2. filtrationFiltration
  3. customyielded a white solid, which
  4. washwas then washed with ether
  5. customdried in vacuo to constant weight

Sources & evidence

ORD record
ord-c35d75ee4e0a4b42801e8a21fcc5aea0
Source dataset
uspto-grants-1981_11
Patent number
US04299842

Reaction notes

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