Triethylamine → HCID 131726535, compound

To a stirring solution of (R)—N-(tert-butyloxycarbonyl)-α-methylphenylalanine (0.72 g, 2.6 mmol) in dry CH2Cl2 (16 mL) was added N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (0.69 g, 4.4 mmol) and 1-hydroxybenzotriazole hydrate (0.39 g, 2.9 mmol). The reaction was stirred at ambient temperature for 30 min and then glycine, ethyl ester hydrochloride (0.62 g, 5.2 mmol) and triethylamine (0.85 ml, 5.7 mmol) were added. After stirring at ambient temperature for 3 h, the reaction was transferred to a separatory funnel with CH2Cl2. Extraction with CH2Cl2 and washing of the organic layer with water, saturated NaHCO3, and brine and drying with MgSO4 afforded 0.94 g of crude product after evaporation of the solvent. Purification by flash chromatography (SiO2, 0.2 to 10% MeOH in CH2Cl2) afforded pure product (0.87 g, 93% yield). MS (ESI) 365 (M+H).

1. stirringAfter stirring at ambient temperature for 3 h
2. extractionExtraction with CH2Cl2
3. washwashing of the organic layer with water, saturated NaHCO3, and brine
4. dry with materialdrying with MgSO4
5. customafforded 0.94 g of crude product
6. customafter evaporation of the solvent
7. customPurification by flash chromatography (SiO2, 0.2 to 10% MeOH in CH2Cl2)

ORD record

ord-fe3f339e5f224f21840cab778a5947d4

Source dataset

uspto-grants-2010_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07812024B2