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Methanol → Methyl 4-(allylamino)-3-fluoro-2-(2-fluoro-4-iodophenylamino)-5-nitrobenzoate

HRID 1161784
Notes
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Reaction equation

HRID 1161784 reaction equation
[F:1][C:2]1[C:3]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([I:23])=[CH:19][C:18]=2[F:24])=[C:4]([CH:9]=[C:10]([N+:13]([O-:15])=[O:14])[C:11]=1F)[C:5]([O:7][CH3:8])=[O:6].[CH2:25]([NH2:28])[CH:26]=[CH2:27].CO.O>C1COCC1>[CH2:25]([NH:28][C:11]1[C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[C:3]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([I:23])=[CH:19][C:18]=2[F:24])[C:2]=1[F:1])[CH:26]=[CH2:27]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 7853AllylamineHCID 58781115Methyl 3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-5-nitrobenzoate

Product 1

HCID 58781109Methyl 4-(allylamino)-3-fluoro-2-(2-fluoro-4-iodophenylamino)-5-nitrobenzoate

Reagents, catalysts & solvents 1

HCID 8028
Tetrahydrofuran
Solvent

Procedure

A suspension of methyl 3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-5-nitrobenzoate (3.9 g, 8.62 mmoles) and allylamine (3.5 ml, 43 mmoles) in a mixture of THF (10 ml), MeOH (10 ml) and H2O (2.5 ml) is stirred at room temperature for 30 min. The yellow suspension is filtered and washed with hexane to remove the excess of allylamine. The resulting solid is dried under vacuum to obtain the title compound.

Workup

  1. filtrationThe yellow suspension is filtered
  2. washwashed with hexane
  3. customto remove the excess of allylamine
  4. customThe resulting solid is dried under vacuum

Sources & evidence

ORD record
ord-af9d7ea2af7b42e38cd680fccb76e87a
Source dataset
uspto-grants-2010_10
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07820664B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes