Hydrochloric Acid → 1-(Prop-2-en-1-yl)piperazin-2-one
Reaction equation
[CH2:1]([N:4]1[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][C:5]1=[O:17])[CH:2]=[CH2:3].Cl>CCOC(C)=O>[CH2:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][C:5]1=[O:17])[CH:2]=[CH2:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
Into a stirred solution of 1-(2-propenyl)-4-tert-butyloxycarbonyl-2-piperazinone (11 g, 46 mmol) in EtOAc (100 mL) at 0° C. was bubbled HCl gas for 10 min. The mixture was stirred at 0° C. for 30 min and then at ambient temperature for 1 h. The solvent was removed in vacuo to yield the hydrochloride salt of the title compound as a white solid. ES MS (M+H)=141.
Workup
- waitat ambient temperature for 1 h
- customThe solvent was removed in vacuo
Sources & evidence
- ORD record
- ord-9300c0339c024c21ab4b2edce0e23cd6
- Source dataset
- uspto-grants-2010_10
- Patent number
- US07820680B2
Reaction notes
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