Hydrochloric Acid → 5-Methyl-pyridine-2-sulfonic acid [2-[2-(methanesulfonylamino-methyl)-pyridin-4-yl]-6-methoxy-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-amide

HRID 116465

Reaction equation

HRID 116465 reaction equation
[CH2:38]([N:39]([CH:40]([CH3:41])[CH3:42])[CH:43]([CH3:44])[CH3:45])[CH3:46].[CH3:47][S:48]([Cl:49])(=[O:50])=[O:51].[CH3:59][OH:60].[Cl:53][CH2:54][Cl:55].[Cl:56][CH2:57][Cl:58].[ClH:1].[ClH:52].[NH2:2][CH2:3][c:4]1[n:5][cH:6][cH:7][c:8](-[c:10]2[n:11][c:12]([O:36][CH3:37])[c:13]([O:27][c:28]3[c:29]([O:34][CH3:35])[cH:30][cH:31][cH:32][cH:33]3)[c:14]([NH:16][S:17](=[O:18])(=[O:19])[c:20]3[n:21][cH:22][c:23]([CH3:26])[cH:24][cH:25]3)[n:15]2)[cH:9]1>>[NH:2]([CH2:3][c:4]1[n:5][cH:6][cH:7][c:8](-[c:10]2[n:11][c:12]([O:36][CH3:37])[c:13]([O:27][c:28]3[c:29]([O:34][CH3:35])[cH:30][cH:31][cH:32][cH:33]3)[c:14]([NH:16][S:17](=[O:18])(=[O:19])[c:20]3[n:21][cH:22][c:23]([CH3:26])[cH:24][cH:25]3)[n:15]2)[cH:9]1)[S:48]([CH3:47])(=[O:50])=[O:51]

Participants

7

Reactant 6

HCID 313Hydrochloric Acid2×HCID 887MethanolHCID 6344Dichloromethane2×HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 54564083N-[2-[2-(aminomethyl)-4-pyridinyl]-6-methoxy-5-(2-methoxyphenoxy)pyrimidin-4-yl]-5-methylpyridine-2-sulfonamide

Product 1

HCID 98731685-Methyl-pyridine-2-sulfonic acid [2-[2-(methanesulfonylamino-methyl)-pyridin-4-yl]-6-methoxy-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-amide

Sources & evidence

ORD record
ord-3bff15ff318a48c386e870eaa000ef49
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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