Hydrochloric Acid → {2-[3,5-Bis(trifluoromethyl)phenyl]ethyl}{[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amine

HRID 118255

Reaction equation

HRID 118255 reaction equation
[BH3:41].[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[ClH:42].[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:13][C:14](=[O:15])[NH:16][CH2:17][c:18]2[c:19](-[c:28]3[c:29]([O:37][CH3:38])[cH:30][cH:31][c:32]([CH:34]([CH3:35])[CH3:36])[cH:33]3)[cH:20][cH:21][c:22]([C:24]([F:25])([F:26])[F:27])[cH:23]2)[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:39])[F:40].[Na+:44].[OH-:43]>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:13][CH2:14][NH:16][CH2:17][c:18]2[c:19](-[c:28]3[c:29]([O:37][CH3:38])[cH:30][cH:31][c:32]([CH:34]([CH3:35])[CH3:36])[cH:33]3)[cH:20][cH:21][c:22]([C:24]([F:25])([F:26])[F:27])[cH:23]2)[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:39])[F:40]

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 961HydroxideHCID 6331BoraneHCID 8028TetrahydrofuranHCID 866153972-[3,5-bis(trifluoromethyl)phenyl]-N-{[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}acetamide

Product 1

HCID 86615398{2-[3,5-Bis(trifluoromethyl)phenyl]ethyl}{[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amine

Sources & evidence

ORD record
ord-d843d527ac5344dea69cbceb02adc98f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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