Hydrochloric Acid → (S)-3-pyrrolidinyloxyamine dihydrochloride
Reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C@H:10]([O:13][NH2:14])[CH2:9]1)=O)(C)(C)C.[ClH:15]>CCOC(C)=O>[ClH:15].[ClH:15].[NH:8]1[CH2:12][CH2:11][C@H:10]([O:13][NH2:14])[CH2:9]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
(S)-1-tert-Butoxycarbonyl-3-pyrrolidinyloxyamine (1.67 g) was dissolved in a 5M HCl solution in EtOAc (20 ml). After 1 h the solvent was removed under reduced pressure to give (S)-3-pyrrolidinyloxyamine dihydrochloride (1.04 g, 73%) as an off-white solid.
Workup
- customAfter 1 h the solvent was removed under reduced pressure
Sources & evidence
- ORD record
- ord-35385a8623954518b105a35237cf0d91
- Source dataset
- uspto-grants-2014_03
- Patent number
- US08664210B2
Reaction notes
Loading…