Diethylamine → H-Orn(Z)-OH

HRID 11838

Reaction equation

HRID 11838 reaction equation
C([NH:18][C@H:19]([C:34]([OH:36])=[O:35])[CH2:20][CH2:21][CH2:22][NH:23][C:24]([O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:25])(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.C(NCC)C>CN(C=O)C>[C:24]([NH:23][CH2:22][CH2:21][CH2:20][C@@H:19]([C:34]([OH:36])=[O:35])[NH2:18])([O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:25]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 14999635Fmoc-orn(Z)-OH

Product 1

HCID 7009570H-Orn(Z)-OHYield 199.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound obtained in Example 8-5 (122.8 mg) was dissolved in DMF (2.6 ml). After the addition of diethylamine (0.26 ml), the mixture was stirred for 2 hours at room temperature. After the reaction, the solvent was removed by distillation under reduced pressure and the residue was dried under vacuum to obtain the title compound (133.5 mg).

Workup

  1. customAfter the reaction
  2. customthe solvent was removed by distillation under reduced pressure
  3. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-5fa1bf7313374de8b97081467abfed33
Source dataset
uspto-grants-2006_08
Patent number
US07098215B2

Linked notes

Loading…