Potassium Carbonate → HCID 67401954, compound

HRID 1186371Notes

Reaction equation

HRID 1186371 reaction equation
[Cl:1][C:2]1[S:3][C:4]([CH:7]=[O:8])=[CH:5][N:6]=1.C(=O)([O-])[O-].[K+].[K+].[F:15][C:16]([Si](C)(C)C)([F:18])[F:17]>CN(C)C=O>[Cl:1][C:2]1[S:3][C:4]([CH:7]([OH:8])[C:16]([F:18])([F:17])[F:15])=[CH:5][N:6]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 552549(Trifluoromethyl)trimethylsilaneHCID 14797652-Chloro-1,3-thiazole-5-carbaldehyde

Product 1

HCID 67401954HCID 67401954, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

According to Reference Example 8-2, by use of 2-chlorothiazole-5-carbaldehyde (300 mg, 2.03 mmol) dissolved in N,N-dimethylformamide (4 mL), potassium carbonate (56 mg, 0.41 mmol) and (trifluoromethyl)trimethylsilane (0.360 mL, 2.44 mmol), the mixture was stirred and reacted at room temperature for 1.3 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give

Workup

  1. customreacted at room temperature for 1.3 hours
  2. customThen, purification by preparative thin-layer chromatography (chloroform/methanol=15/1)
  3. customto give

Sources & evidence

ORD record
ord-9fb403dcf9c6448d8721f7ff0532fff1
Source dataset
uspto-grants-2014_03
Patent number
US08673908B2

Reaction notes

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