Benzene, 1-(chloromethyl)-2-fluoro- → 1-Benzyl-4-(2-fluorobenzyl)piperidin-4-ol
Reaction equation
[CH2:12]([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[N:19]1[CH2:20][CH2:21][C:22](=[O:25])[CH2:23][CH2:24]1.[F:3][c:4]1[c:5]([CH2:6][Cl:7])[cH:8][cH:9][cH:10][cH:11]1.[I:2].[Mg:1]>>[F:3][c:4]1[c:5]([CH2:6][C:22]2([OH:25])[CH2:21][CH2:20][N:19]([CH2:12][c:13]3[cH:14][cH:15][cH:16][cH:17][cH:18]3)[CH2:24][CH2:23]2)[cH:8][cH:9][cH:10][cH:11]1Participants
5
Sources & evidence
- ORD record
- ord-3bd5f8eadeb7409a882259485e3ad3be
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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