Hydrochloric Acid → HCID 178482234, compound

HRID 1189640Notes

Reaction equation

HRID 1189640 reaction equation
[F:1][C:2]([F:9])([F:8])[CH:3]1[CH2:7][CH2:6][NH:5][CH2:4]1.Cl.CCN(C(C)C)C(C)C.[F:20][C:21]([F:44])([F:43])[C@H:22]1[CH2:27][CH2:26][C@H:25]([NH:28][C:29](=[O:42])[C:30]2[CH:35]=[C:34]([N+:36]([O-:38])=[O:37])[C:33]([NH:39][CH3:40])=[CH:32][C:31]=2F)[CH2:24][CH2:23]1>O.CC#N>[F:20][C:21]([F:43])([F:44])[C@H:22]1[CH2:27][CH2:26][C@H:25]([NH:28][C:29](=[O:42])[C:30]2[CH:35]=[C:34]([N+:36]([O-:38])=[O:37])[C:33]([NH:39][CH3:40])=[CH:32][C:31]=2[N:5]2[CH2:6][CH2:7][CH:3]([C:2]([F:9])([F:8])[F:1])[CH2:4]2)[CH2:24][CH2:23]1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 51521593-(Trifluoromethyl)pyrrolidineHCID 178482229HCID 178482229, compound

Product 1

HCID 178482234HCID 178482234, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

A mixture of 3-trifluoromethyl-pyrrolidine×HCl (53 mg, 0.30 mmol), DIPEA (0.40 ml, 2.4 mmol), N-(trans-4-trifluoromethyl-cyclohexyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide (100 mg, 0.28 mmol) and MeCN (2 mL) is stirred for 4.5 h at reflux. Then the mixture is diluted with water and the formed precipitate is filtered, washed with water and dried

Workup

  1. temperatureat reflux
  2. filtrationthe formed precipitate is filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-6ebbb829a94b4f8086bb4cb2742af89e
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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