Hydrochloric Acid → 4-(5-Bromothiazol-2-yl)-4-hydroxycyclohexanone

Reaction equation

[Br:1][c:2]1[cH:3][n:4][c:5]([C:7]2([OH:17])[CH2:8][CH2:9][C:10]3([O:11][CH2:14][CH2:13][O:12]3)[CH2:15][CH2:16]2)[s:6]1.[CH3:19][CH2:20][O:21][C:22]([CH3:23])=[O:24].[ClH:18].[OH2:25]>>[Br:1][c:2]1[cH:3][n:4][c:5]([C:7]2([OH:17])[CH2:8][CH2:9][C:10](=[O:11])[CH2:15][CH2:16]2)[s:6]1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 962Water

HCID 8857Ethyl Acetate

HCID 672560328-(5-Bromo-1,3-thiazol-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol

Product 1

HCID 672574234-(5-Bromothiazol-2-yl)-4-hydroxycyclohexanone

Sources & evidence

ORD record: ord-44d6f4605abd49c0a0bd290543abd04c
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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