Trifluoroacetic acid → HCID 14368703, compound

Reaction equation

[C:1]1([C:7](C2C=CC=CC=2)(C2C=CC=CC=2)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O[C:26](=O)[C:27]([F:30])(F)F)=O.[F:34][C:35](F)(F)[C:36](O)=O>>[F:30][C:27]1[CH:26]=[C:35]([F:34])[CH:36]=[C:6]2[C:5]=1[CH:4]=[CH:3][CH:2]=[C:1]2[CH3:7]

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 6457Triphenylcarbinol

HCID 9845Trifluoroacetic anhydride

Product 1

HCID 14368703HCID 14368703, compound

Procedure

2.5 g of 5,7-Difluoro-1-methyl-tetralol, 3.6 g of triphenylmethanol and 2.6 g of trifluoroacetic acid anhydride are refluxed for 5 hours in 16 ml of trifluoroacetic acid. The mixture is poured onto ice-water and extracted with dichloromethane. The organic phase is washed neutral with sodium bicarbonate solution, dried and concentrated. The oily crude product can be purified by chromatography over silica gel (eluant:hexane).

Workup

additionThe mixture is poured onto ice-water
extractionextracted with dichloromethane
washThe organic phase is washed neutral with sodium bicarbonate solution
customdried
concentrationconcentrated
customThe oily crude product can be purified by chromatography over silica gel (eluant:hexane)

Sources & evidence

ORD record: ord-ad67fd31fe2446d6979950a44886008f
Source dataset: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05112851

Reaction notes

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