Potassium Carbonate → HCID 178418677, compound

HRID 1198322

Reaction equation

HRID 1198322 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH:5]=[CH:4][C:3]=1[OH:14].[CH2:15]([C@H:20]1[CH2:25][CH2:24][C@H:23]([CH2:26]Br)[CH2:22][CH2:21]1)[CH2:16][CH2:17][CH2:18][CH3:19].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:10]([O:9][C:6]1[CH:5]=[CH:4][C:3]([O:14][CH2:26][C@H:23]2[CH2:24][CH2:25][C@H:20]([CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:21][CH2:22]2)=[C:2]([F:1])[C:7]=1[F:8])[CH2:11][CH2:12][CH3:13]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 191034334-Butoxy-2,3-difluorophenolHCID 178444389HCID 178444389, compound

Product 1

HCID 178418677HCID 178418677, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.1 mol of 2,3-difluoro-4-butoxyphenol, 0.11 mol of trans-4-pentylcyclohexylmethyl bromide and 0.11 mol of potassium carbonate are heated at 100° in 100 ml of dimethylformamide (DMF) for 16 hours. After cooling, the inorganic salts are filtered off with suction, the filtrate is concentrated and water is added. Extraction with methylene chloride gives 1-butoxy-2,3-difluoro-4-(trans-4-pentylcyclohexylmethoxy)benzene.

Workup

  1. temperatureAfter cooling
  2. filtrationthe inorganic salts are filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. additionwater is added
  5. extractionExtraction with methylene chloride

Sources & evidence

ORD record
ord-1bae8b3220744c4abf0f5bfe7aab8377
Source dataset
uspto-grants-1994_01
Patent number
US05279764

Linked notes

Loading…