Water → 5-Chloro-7-morpholinothiazolo[5,4-d]pyrimidine-2-carbaldehyde

Reaction equation

[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:35][C:36]#[N:37].[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([CH:11]=[CH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[n:10]2.[I+3:25]([O-:26])([OH:27])([O-:28])[O-:29].[OH2:38].[Ru:39]([Cl:40])([Cl:41])[Cl:42]>>[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([CH:11]=[O:26])[n:10]2

Participants

Reactant 6

HCID 962Water

HCID 6342Acetonitrile

HCID 8028Tetrahydrofuran

HCID 61850Ruthenium trichloride

HCID 65185Metaperiodic acid

HCID 866436425-Chloro-7-morpholin-4-yl-2-styryl-thiazolo[5,4-d]pyrimidine

Product 1

HCID 576854055-Chloro-7-morpholinothiazolo[5,4-d]pyrimidine-2-carbaldehyde

Sources & evidence

ORD record: ord-8e6ada085aa64d3dae94cc6d3154a336
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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