Dicyclohexylcarbodiimide → Pent-4-ynoylaminooxy-acetic Acid Ethyl Ester

HRID 12009

Reaction equation

HRID 12009 reaction equation
[CH2:1]([O:3][C:4](=[O:8])[CH2:5][O:6][NH2:7])[CH3:2].[C:9](O)(=[O:14])[CH2:10][CH2:11][C:12]#[CH:13].C1(N=C=NC2CCCCC2)CCCCC1>CCOC(C)=O>[CH2:1]([O:3][C:4](=[O:8])[CH2:5][O:6][NH:7][C:9](=[O:14])[CH2:10][CH2:11][C:12]#[CH:13])[CH3:2]

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 198082-Aminoxy-acetic acid ethyl esterHCID 224644-Pentynoic acid

Product 1

HCID 59336531Pent-4-ynoylaminooxy-acetic Acid Ethyl Ester

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 2-Aminoxy-acetic acid ethyl ester (573 mg, 4.8 mmol) and 4-Pentynoic acid (441 mg, 4.5 mmol) in 15 mL EtOAc were added dicyclohexylcarbodiimide (928 mg, 4.5 mmol) and the resulting mixture was stirred at room temperature for 16 h.

Sources & evidence

ORD record
ord-128be03e30fc479198b6496eaff8785b
Source dataset
uspto-grants-2010_06
Patent number
US07727713B2

Linked notes

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