Tetrahydrofuran → Tert-butyl 2-[8-methyl-4-oxo-6-(phenylcarbamoyl)-3-[phenylmethoxycarbonyl(prop-2-enyl)amino]-6,7-dihydropyrrolo[1,2-a]pyrimidin-8-yl]acetate

HRID 1202504

Reaction equation

HRID 1202504 reaction equation
[Br:45][CH2:46][C:47](=[O:48])[O:49][C:50]([CH3:51])([CH3:52])[CH3:53].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9]([N:10]([c:11]1[cH:12][n:13][c:14]2[n:15]([c:16]1=[O:17])[CH:18]([C:22]([NH:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)=[O:30])[CH2:19][CH:20]2[CH3:21])[CH2:31][CH:32]=[CH2:33])=[O:34].[CH2:54]1[O:55][CH2:56][CH2:57][CH2:58]1.[CH3:36][Si:37]([N-:38][Si:39]([CH3:40])([CH3:41])[CH3:42])([CH3:43])[CH3:44].[Li+:35]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9]([N:10]([c:11]1[cH:12][n:13][c:14]2[n:15]([c:16]1=[O:17])[CH:18]([C:22]([NH:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)=[O:30])[CH2:19][C:20]2([CH3:21])[CH2:46][C:47](=[O:48])[O:49][C:50]([CH3:51])([CH3:52])[CH3:53])[CH2:31][CH:32]=[CH2:33])=[O:34]

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 79177tert-Butyl bromoacetateHCID 3280088Npc316347HCID 21041410benzyl N-[8-methyl-4-oxo-6-(phenylcarbamoyl)-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidin-3-yl]-N-prop-2-enylcarbamate

Product 1

HCID 69600882Tert-butyl 2-[8-methyl-4-oxo-6-(phenylcarbamoyl)-3-[phenylmethoxycarbonyl(prop-2-enyl)amino]-6,7-dihydropyrrolo[1,2-a]pyrimidin-8-yl]acetate

Sources & evidence

ORD record
ord-f9bb7edee5a8429295e3224cfcaa0369
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Linked notes

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