Toluene → 2-(1-(4-Chloro-3-methoxyphenyl)piperidin-4-ylidene)ethanol

Reaction equation

[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:21][CH:22]([CH2:23][AlH:24][CH2:25][CH:26]([CH3:27])[CH3:28])[CH3:29].[CH3:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1.[Cl:1][c:2]1[c:3]([O:19][CH3:20])[cH:4][c:5]([N:8]2[CH2:9][CH2:10][C:11](=[CH:14][C:15](=[O:16])[O:17][CH3:18])[CH2:12][CH2:13]2)[cH:6][cH:7]1>>[Cl:1][c:2]1[c:3]([O:19][CH3:20])[cH:4][c:5]([N:8]2[CH2:9][CH2:10][C:11](=[CH:14][CH2:15][OH:16])[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

Reactant 4

HCID 1140Toluene

HCID 8028Tetrahydrofuran

HCID 14487Diisobutylaluminum hydride

HCID 68557054HCID 68557054, compound

Product 1

HCID 685548602-(1-(4-Chloro-3-methoxyphenyl)piperidin-4-ylidene)ethanol

Sources & evidence

ORD record: ord-885e7521159a4aef9af73b1a28107425
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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