Methane → 4-(1,6-diazaspiro[3.5]non-6-yl)-7H-pyrrolo[2,3-d]pyrimidine

Reaction equation

[C:36].[CH2:1]([O:2][C:3](=[O:4])[N:11]1[CH2:12][CH2:13][C:14]12[CH2:15][N:16]([c:20]1[c:21]3[c:22]([n:23][cH:24][n:25]1)[nH:26][cH:27][cH:28]3)[CH2:17][CH2:18][CH2:19]2)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:34][OH:35].[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1.[Pd:37]>>[NH:11]1[CH2:12][CH2:13][C:14]12[CH2:15][N:16]([c:20]1[c:21]3[c:22]([n:23][cH:24][n:25]1)[nH:26][cH:27][cH:28]3)[CH2:17][CH2:18][CH2:19]2

Participants

Reactant 5

HCID 297Methane

HCID 887Methanol

HCID 8028Tetrahydrofuran

HCID 23938Palladium

HCID 582933616-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.5]nonane-1-carboxylic acid benzyl ester

Product 1

HCID 582933334-(1,6-diazaspiro[3.5]non-6-yl)-7H-pyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record: ord-2a36548e0fdc4bc49f7845bf8b847625
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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