Acetate → 2-Fluoro-4-methoxy-3-(1,4,4,6-tetramethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-benzaldehyde

HRID 1206377

Reaction equation

HRID 1206377 reaction equation
[Ba+2:58].[Br:1][c:2]1[c:3]([CH3:16])[cH:4][c:5]2[c:10]([cH:11]1)[N:9]([CH3:12])[C:8](=[O:13])[CH2:7][C:6]2([CH3:14])[CH3:15].[C:83]([O-:84])(=[O:85])[CH3:86].[C:88]([O-:89])(=[O:90])[CH3:91].[CH2:78]1[O:79][CH2:80][CH2:81][CH2:82]1.[CH3:17][CH2:18][N:19]([CH2:20][CH3:21])[CH2:22][CH3:23].[CH:24]1([P:25]([CH:26]2[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]2)[c:32]2[cH:33][cH:34][cH:35][cH:36][c:37]2-[c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48]1.[F:60][c:61]1[c:62]([CH:63]=[O:64])[cH:65][cH:66][c:67]([O:70][CH3:71])[c:68]1[I:69].[O:72]1[CH2:73][CH2:74][O:75][CH2:76][CH2:77]1.[OH-:57].[OH-:59].[OH2:49].[OH2:50].[OH2:51].[OH2:52].[OH2:53].[OH2:54].[OH2:55].[OH2:56].[OH2:92].[Pd+2:87]>>[c:2]1(-[c:68]2[c:61]([F:60])[c:62]([CH:63]=[O:64])[cH:65][cH:66][c:67]2[O:70][CH3:71])[c:3]([CH3:16])[cH:4][c:5]2[c:10]([cH:11]1)[N:9]([CH3:12])[C:8](=[O:13])[CH2:7][C:6]2([CH3:14])[CH3:15]

Participants

12

Reactant 11

HCID 175Acetate2×HCID 961Hydroxide2×HCID 962Water9×HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 312751,4-DioxaneHCID 104810Barium ionHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27342162-(Dicyclohexylphosphino)biphenylHCID 219664297-bromo-1,4,4,6-tetramethyl-3,4-dihydro-1H-quinoline-2-oneHCID 219664772-Fluoro-3-iodo-4-methoxybenzaldehyde

Product 1

HCID 219664782-Fluoro-4-methoxy-3-(1,4,4,6-tetramethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-benzaldehyde

Sources & evidence

ORD record
ord-5bd40aaac5984dd0b771725d556cb2fe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Linked notes

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