Tetrahydrofuran → 3-(2,6-Dichloro-4-methoxy-benzyl)-1-(1,4-dioxa-spiro[4.5]dec-8-yl)-pyrrolidin-2-one

HRID 1207103

Reaction equation

HRID 1207103 reaction equation
[Br:25][CH2:26][c:27]1[c:28]([Cl:36])[cH:29][c:30]([O:34][CH3:35])[cH:31][c:32]1[Cl:33].[CH3:18][CH:19]([N-:20][CH:21]([CH3:22])[CH3:23])[CH3:24].[Li+:17].[O:1]1[CH2:2][CH2:3][O:4][C:5]12[CH2:6][CH2:7][CH:8]([N:11]1[C:12](=[O:16])[CH2:13][CH2:14][CH2:15]1)[CH2:9][CH2:10]2.[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1>>[O:1]1[CH2:2][CH2:3][O:4][C:5]12[CH2:6][CH2:7][CH:8]([N:11]1[C:12](=[O:16])[CH:13]([CH2:26][c:27]3[c:28]([Cl:36])[cH:29][c:30]([O:34][CH3:35])[cH:31][c:32]3[Cl:33])[CH2:14][CH2:15]1)[CH2:9][CH2:10]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 5062348DiisopropylamideHCID 109002931-(1,4-Dioxaspiro[4.5]decan-8-yl)pyrrolidin-2-oneHCID 592994792-(Bromomethyl)-1,3-dichloro-5-methoxybenzene

Product 1

HCID 578785993-(2,6-Dichloro-4-methoxy-benzyl)-1-(1,4-dioxa-spiro[4.5]dec-8-yl)-pyrrolidin-2-one

Sources & evidence

ORD record
ord-f1b88c6cd2e049f09eaf68331d7e5b55
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Linked notes

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