N-methyl-2-pyrrolidone → 7-[5-(Trifluoromethyl)pyridin-2-yl]-2,7-diazaspiro[4.5]decan-1-one
Reaction equation
[C:1]1(=[O:11])[NH:2][CH2:3][CH2:4][C:5]12[CH2:6][NH:7][CH2:8][CH2:9][CH2:10]2.[CH3:32][N:33]1[CH2:34][CH2:35][CH2:36][C:37]1=[O:38].[CH:23]([N:24]([CH2:25][CH3:26])[CH:27]([CH3:28])[CH3:29])([CH3:30])[CH3:31].[Cl:12][c:13]1[n:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]1>>[C:1]1(=[O:11])[NH:2][CH2:3][CH2:4][C:5]12[CH2:6][N:7]([c:13]1[n:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]1)[CH2:8][CH2:9][CH2:10]2Participants
5
Sources & evidence
- ORD record
- ord-13cad508c6c346b7a239206ce712aa91
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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