Hydroxide → N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methylbenzamide

HRID 122480

Reaction equation

HRID 122480 reaction equation
[Br:1][c:2]1[c:3]([F:12])[c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][c:10]2[NH2:11].[CH3:13][c:14]1[cH:15][cH:16][cH:17][c:18]([C:20]([OH:21])=[O:22])[cH:19]1.[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[Cl:32][CH2:33][Cl:34].[Li+:31].[OH-:30].[OH2:35]>>[Br:1][c:2]1[c:3]([F:12])[c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][c:10]2[NH:11][C:20]([c:18]1[cH:17][cH:16][cH:15][c:14]([CH3:13])[cH:19]1)=[O:21]

Participants

8

Reactant 7

HCID 961HydroxideHCID 962WaterHCID 6344DichloromethaneHCID 74183-Methylbenzoic acidHCID 8471TriethylamineHCID 28486Lithium ionHCID 602052765-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine

Product 1

HCID 60205331N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methylbenzamide

Sources & evidence

ORD record
ord-a5ce9f1122734961a4b2b3dc6374abe5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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