Hydrochloric Acid → (+/-)-6,7-Dimethoxy-2-{[1-(tert-butyloxycarbonyl)-3-piperidyl]carbonyl}-1,2,3,4-tetrahydroisoquinoline

HRID 122571

Reaction equation

HRID 122571 reaction equation
[C:15]([CH3:16])([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[N:22]1[CH2:23][CH:24]([C:25](=[O:26])[OH:27])[CH2:28][CH2:29][CH2:30]1.[CH2:32]([N:33]=[C:34]=[N:35][CH2:36][CH2:37][CH2:38][N:39]([CH3:40])[CH3:41])[CH3:42].[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:10]([cH:11][c:12]1[O:13][CH3:14])[CH2:9][NH:8][CH2:7][CH2:6]2.[Cl:53][CH2:54][Cl:55].[ClH:31].[OH:43][n:44]1[c:45]2[cH:46][cH:47][cH:48][cH:49][c:50]2[n:51][n:52]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:10]([cH:11][c:12]1[O:13][CH3:14])[CH2:9][N:8]([C:25]([CH:24]1[CH2:23][N:22]([C:20]([O:19][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:21])[CH2:30][CH2:29][CH2:28]1)=[O:26])[CH2:7][CH2:6]2

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 156236,7-Dimethoxy-1,2,3,4-TetrahydroisoquinolineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 27356471-((Tert-butoxy)carbonyl)piperidine-3-carboxylic acid

Product 1

HCID 18520105(+/-)-6,7-Dimethoxy-2-{[1-(tert-butyloxycarbonyl)-3-piperidyl]carbonyl}-1,2,3,4-tetrahydroisoquinoline

Sources & evidence

ORD record
ord-70961b2f1a4c4edb8c09bd1586391b6e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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