Tetrahydrofuran → 4-[2-(t-Butyldimethyl silyloxy)ethyl]-1-(6-trifluoromethyl benzothiazole-2-yl)piperidine-4-carbonitrile
Reaction equation
[Br:32][CH2:33][CH2:34][O:35][Si:36]([CH3:37])([CH3:38])[C:39]([CH3:40])([CH3:41])[CH3:42].[CH3:22][Si:23]([N-:24][Si:25]([CH3:26])([CH3:27])[CH3:28])([CH3:29])[CH3:30].[F:1][C:2]([c:3]1[cH:4][c:5]2[c:6]([n:7][c:8]([N:10]3[CH2:11][CH2:12][CH:13]([C:16]#[N:17])[CH2:14][CH2:15]3)[s:9]2)[cH:18][cH:19]1)([F:20])[F:21].[Li+:31].[O:43]1[CH2:44][CH2:45][CH2:46][CH2:47]1>>[F:1][C:2]([c:3]1[cH:4][c:5]2[c:6]([n:7][c:8]([N:10]3[CH2:11][CH2:12][C:13]([C:16]#[N:17])([CH2:33][CH2:34][O:35][Si:36]([CH3:37])([CH3:38])[C:39]([CH3:40])([CH3:41])[CH3:42])[CH2:14][CH2:15]3)[s:9]2)[cH:18][cH:19]1)([F:20])[F:21]
