Diethylamine → HCID 85961308, compound

HRID 1244256

Reaction equation

HRID 1244256 reaction equation
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[CH2:6]([O:8][C:9]([C:11]1[N:12]=[N:13][C:14]([Cl:18])=[CH:15][C:16]=1Cl)=[O:10])[CH3:7]>C(OCC)(=O)C>[CH2:6]([O:8][C:9]([C:11]1[N:12]=[N:13][C:14]([Cl:18])=[CH:15][C:16]=1[N:3]([CH2:4][CH3:5])[CH2:1][CH3:2])=[O:10])[CH3:7]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 53428795Ethyl 4,6-dichloropyridazine-3-carboxylate

Product 1

HCID 85961308HCID 85961308, compoundYield 98.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Diethylamine (86 mg, 1.3 equivalents, 1.2 mmol) is added to a solution of 4,6-dichloro-pyridazine-3-carboxylic acid ethyl ester (0.2 g, 0.91 mmol) in ethyl acetate (10 mL) at room temperature. After overnight stirring, the reaction is quenched with water (6 mL). The organic layer is separated and the aqueous layer extracted (2×15 mL) with ethyl acetate. The combined organic layers are dried and solvent removed to give 230 mg of 6-chloro-4-diethylamino-pyridazine-3-carboxylic acid ethyl ester as a yellowish oil.

Workup

  1. customthe reaction is quenched with water (6 mL)
  2. customThe organic layer is separated
  3. extractionthe aqueous layer extracted (2×15 mL) with ethyl acetate
  4. customThe combined organic layers are dried
  5. customsolvent removed

Sources & evidence

ORD record
ord-9e8b97256656485b83fc086a99a545bc
Source dataset
uspto-grants-2006_10
Patent number
US07122546B2

Linked notes

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