Tetrahydrofuran → N-(3-(2-(2-chloropyriMidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

HRID 124586

Reaction equation

HRID 124586 reaction equation
[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:24][Si:25]([N-:26][Si:27]([CH3:28])([CH3:29])[CH3:30])([CH3:31])[CH3:32].[Cl:34][c:35]1[n:36][cH:37][cH:38][c:39]([CH3:41])[n:40]1.[F:1][c:2]1[c:3]([S:9](=[O:10])(=[O:11])[NH:12][c:13]2[c:14]([F:23])[c:15]([C:16](=[O:17])[O:18][CH3:19])[cH:20][cH:21][cH:22]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1.[Li+:33]>>[F:1][c:2]1[c:3]([S:9](=[O:10])(=[O:11])[NH:12][c:13]2[c:14]([F:23])[c:15]([C:16](=[O:17])[CH2:41][c:39]3[cH:38][cH:37][n:36][c:35]([Cl:34])[n:40]3)[cH:20][cH:21][cH:22]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 3280088Npc316347HCID 116296072-Chloro-4-methylpyrimidineHCID 57989692Benzoic acid, 3-[[(2,6-difluorophenyl)sulfonyl]amino]-2-fluoro-, methyl ester

Product 1

HCID 57989720N-(3-(2-(2-chloropyriMidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-448faac1a4cd4ceea9d4221ed08f0e76
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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