Tetrahydrofuran → N-(3-(2-(2-chloropyriMidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Reaction equation
[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:24][Si:25]([N-:26][Si:27]([CH3:28])([CH3:29])[CH3:30])([CH3:31])[CH3:32].[Cl:34][c:35]1[n:36][cH:37][cH:38][c:39]([CH3:41])[n:40]1.[F:1][c:2]1[c:3]([S:9](=[O:10])(=[O:11])[NH:12][c:13]2[c:14]([F:23])[c:15]([C:16](=[O:17])[O:18][CH3:19])[cH:20][cH:21][cH:22]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1.[Li+:33]>>[F:1][c:2]1[c:3]([S:9](=[O:10])(=[O:11])[NH:12][c:13]2[c:14]([F:23])[c:15]([C:16](=[O:17])[CH2:41][c:39]3[cH:38][cH:37][n:36][c:35]([Cl:34])[n:40]3)[cH:20][cH:21][cH:22]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1
