Methanol → 6-(4-Carboxy-1H-benzoimidazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([C:18]([NH:19][c:20]3[n:21][c:22]4[c:23]([nH:24]3)[cH:25][cH:26][cH:27][c:28]4[C:29](=[O:30])[O:31][CH3:32])=[O:33])[cH:14][c:15]2[CH2:16][CH2:17]1.[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:41][OH:42].[Li+:35].[OH-:34]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([C:18]([NH:19][c:20]3[n:21][c:22]4[c:23]([nH:24]3)[cH:25][cH:26][cH:27][c:28]4[C:29](=[O:30])[OH:31])=[O:33])[cH:14][c:15]2[CH2:16][CH2:17]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-b1e74623ff394459a5f8f4da3e305667
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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