Lonidamine → HCID 11653177, compound

HRID 1256627

Reaction equation

[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N:8]2)=[C:4](C)[CH:3]=1.[Cl:24]C1C=C(Cl)C=CC=1CN1C2C(=CC=CC=2)C(C(O)=O)=N1.ClC1C=CC(CN2C3C(=CC=CC=3)C(C(O)=O)=N2)=C(C)C=1>>[Cl:24][C:4]1[CH:3]=[C:2]([Cl:1])[CH:22]=[CH:21][C:5]=1[CH2:6][N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N:8]1

Participants

Reactant 3

HCID 39562Lonidamine

HCID 68679Tolnidamine

HCID 67092644HCID 67092644, compound

Product 1

HCID 11653177HCID 11653177, compound

Procedure

The product was obtained using the method described for the preparation of compound 10a, but using as reagent 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid, prepared as described in J. Med. Chem. (1976) 19, 778-783, (0.4 mol) instead of 1-(4-chloro-2-methylbenzyl)-1H-indazole-3-carboxylic acid.

Workup

customThe product was obtained
customprepared

Sources & evidence

ORD record: ord-a9aa5fe1388645489a8961e2b174bf24
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08461194B2

Linked notes

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