Oxalyl chloride → HCID 58127969, compound
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH2:11][C:12]([OH:14])=O)[CH:10]=1)=[O:5])[CH3:2].C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C)C=O>[Cl:18][C:12](=[O:14])[CH2:11][N:9]1[CH:10]=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:7]=[N:8]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of the compound (2.0 g) obtained in Example 115b in dichloromethane (20 mL) was cooled in an ice bath, and oxalyl chloride (2.5 g) and N,N-dimethylformamide (2 drops) were added. The reaction mixture was stirred at room temperature overnight and the solvent was evaporated under reduced pressure to give the title compound.
Workup
- customthe solvent was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-8acc7315a6ef47b78335a24e36382fe9
- Source dataset
- uspto-grants-2013_06
- Patent number
- US08461348B2
Reaction notes
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