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Hydrochloric Acid → 4-Carbamoyl-imidazo-[1,2-a]-quinoxaline-2-carboxylic acid

HRID 126775
Notes
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Reaction equation

HRID 126775 reaction equation
[C:1]([C:4]1[C:5]2[N:6]([CH:14]=[C:15]([C:17]([O:19]CC)=[O:18])[N:16]=2)[C:7]2[C:12]([N:13]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2)(=[O:3])[NH2:2].[OH-].[Na+].[Na].Cl>C(O)C.O>[C:1]([C:4]1[C:5]2[N:6]([CH:14]=[C:15]([C:17]([OH:19])=[O:18])[N:16]=2)[C:7]2[C:12]([N:13]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2)(=[O:3])[NH2:2]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 5360545SodiumHCID 14067521Ethyl 4-carbamoyl-imidazo-[1,2-a]-quinoxaline-2-carboxylate

Product 1

HCID 140675224-Carbamoyl-imidazo-[1,2-a]-quinoxaline-2-carboxylic acidYield 98.6%

Reagents, catalysts & solvents 2

HCID 702
Ethanol
Solvent
HCID 962WaterSolvent

Procedure

A suspension of 0.315 g of the product of Step B, 35 ml of water, 12 ml of ethanol and 6 ml of 1 N sodium hydroxide was stirred overnight to obtain a suspension of the white sodium salt which was acidified with concentrated hydrochloric acid. The mixture was filtered to obtain 0.28 g of 4-carbamoyl-imidazo-[1,2-a]-quinoxaline-2-carboxylic acid in the form of a buff crystalline solid melting at 298°-300° C.

Workup

  1. customto obtain
  2. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-18f30057d9944392968299950e96f77e
Source dataset
uspto-grants-1981_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04254123

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes