O-Cresol → Benzene, 1,1'-oxybis[methyl-
Reaction equation
[C:1]1([CH3:8])[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][CH:2]=1.IC1C=CC=CC=1.I[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23].C(#N)C>CN(C=O)C>[C:1]1([CH3:8])[C:6]([O:7][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])=[CH:5][CH:4]=[CH:3][CH:2]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
Example 3.1 was repeated, replacing the phenol with 206 μl of o-cresol (2 mmoles) and the iodobenzene with 383 μl of 2-iodotoluene (3 mmoles), the acetonitrile with DMF, and with the nucleophile and the arylation agent being added at the same time as the solvent.
Sources & evidence
- ORD record
- ord-d4139118a0e14521a2c0cffc395a74db
- Source dataset
- uspto-grants-2007_04
- Patent number
- US07202367B2
Reaction notes
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