Chloride → 2-Methyl-3,4,6-trifluorobenzoyl chloride

Reaction equation

[CH3:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[C:7]([F:13])[C:3]=1[C:4](O)=[O:5].[Cl-:14]>>[CH3:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[C:7]([F:13])[C:3]=1[C:4]([Cl:14])=[O:5]

Participants

Reactant 2

HCID 312Chloride

HCID 101303052-Methyl-3,4,6-trifluorobenzoic acid

Product 1

HCID 150076072-Methyl-3,4,6-trifluorobenzoyl chloride

Procedure

To 2-methyl-3,4,6-trifluorobenzoic acid (3.2 g) is added thiony chloride (7 ml) and the mixture is refluxed for 1 hour. After concentrating, 2-methyl-3,4,6-trifluorobenzoyl chloride (3.3 g) is obtained.

Workup

temperaturethe mixture is refluxed for 1 hour
concentrationAfter concentrating

Sources & evidence

ORD record: ord-141b4f862c4146f6950ca566cd749152
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05723648

Reaction notes

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