O-Xylene → HCID 18428552, compound

Reaction equation

C([OH:6])/C=C\CC.[H-].[Na+].[Cl:9][C:10]([Cl:14])([Cl:13])[C:11]#[N:12].[C:15]1([CH3:22])[C:16](C)=[CH:17]C=C[CH:20]=1>>[Cl:9][C:10]([Cl:14])([Cl:13])[C:11]([NH:12][CH2:22][C:15](=[CH2:20])[CH2:16][CH3:17])=[O:6]

Participants

Reactant 4

HCID 7237O-Xylene

HCID 11011Trichloroacetonitrile

HCID 24758Sodium hydride

HCID 5364919cis-Pent-2-ene-1-ol

Product 1

HCID 18428552HCID 18428552, compound

Procedure

Cis-2-pentene-1-ol was treated with NaH and trichloroacetonitrile followed by work up and treatment in refluxing xylene by the method of EXAMPLE 208 to produce the material.

Workup

customto produce the material

Sources & evidence

ORD record: ord-c3136d62335544b0a609185205a03166
Source dataset: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06448286B1

Reaction notes

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