Water → HCID 15571500, compound

HRID 127961

Reaction equation

HRID 127961 reaction equation
[CH:1]1([N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)(O)[O-].[Na+].[S:20]([C:24]1[CH:25]=[C:26]([CH:30]=[CH:31][C:32]=1[Cl:33])[C:27](Cl)=[O:28])(=[O:23])(=[O:22])[NH2:21].O>C(O)(C)C>[CH:9]1([N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[NH:8][C:27](=[O:28])[C:26]2[CH:30]=[CH:31][C:32]([Cl:33])=[C:24]([S:20](=[O:22])(=[O:23])[NH2:21])[CH:25]=2)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

6

Reactant 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 30179793-(Aminosulfonyl)-4-chlorobenzoyl chlorideHCID 128663281-Cyclohexyl-1-phenyl-hydrazine

Product 1

HCID 15571500HCID 15571500, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 8.5 g (0.045 mol) 1-cyclohexyl-1-phenyl hydrazine in 50 ml isopropanol and 4.7 g (0.045 mol) sodium bicarbonate was stirred and chilled. Addition of 11.36 g (0.045 mol) 3-sulfamoyl-4-chlorobenzoyl chloride was made in several portions. The mixture was stirred for 2 hours at room temperature and for 2.5 hours at 40°-50° C. Dilution of the reaction mixture with water yielded a solid material which was recrystallized from aqueous ethanol. M.P. 216°-217° C.

Workup

  1. temperaturechilled
  2. stirringThe mixture was stirred for 2 hours at room temperature and for 2.5 hours at 40°-50° C
  3. customwas recrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-3b94d622df534980ab8e261ba30bb99e
Source dataset
uspto-grants-1981_03
Patent number
US04258059

Linked notes

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