1-Bromopropane → HCID 19374328, compound

HRID 128611Notes

Reaction equation

HRID 128611 reaction equation
[OH:1][C:2]1[C:3]([CH3:8])=[N:4][CH:5]=[CH:6][CH:7]=1.[Na].Br[CH2:11][CH2:12][CH3:13]>C(O)CC>[CH3:8][C:3]1[C:2]([O:1][CH2:11][CH2:12][CH3:13])=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

5

Reactant 3

HCID 78401-BromopropaneHCID 707192-Methylpyridin-3-olHCID 5360545Sodium

Product 1

HCID 19374328HCID 19374328, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent2×

Procedure

3-Hydroxy-2-methylpyridine (50 g) was added to a solution of sodium (11.6 g) in propan-1-ol (250 ml) and the mixture treated with 1-bromopropane (51 ml) in propan-1-ol (50 ml) to give 2-methyl-3-propoxypyridine, b.p. 96°-104° C. (30 mmHg).

Sources & evidence

ORD record
ord-9e6b084079f44c2d845926ea4abf4213
Source dataset
uspto-grants-1995_11
Patent number
US05464781

Reaction notes

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