3-Bromopyridine → Biphenyl

HRID 1286117Notes

Reaction equation

HRID 1286117 reaction equation
Brc1cccnc1.N=C(N)Cc1ccccc1>CN1CCCN2CCCN=C12.CS(=O)(=O)[O][Pd]1(<-[NH2]c2ccccc2-c2cccc[c]21)<-[P](c1ccccc1)(c1ccccc1)c1ccc2ccccc2c1-c1c(P(c2ccccc2)c2ccccc2)ccc2ccccc12.CS(C)=O>N=C(Cc1ccccc1)Nc1cccnc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 27787Benzeneethanimidamide

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 27787BenzeneethanimidamideHCID 178510790HCID 178510790, compound

Reagents, catalysts & solvents 3

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneReagentHCID 178505363HCID 178505363, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-fee82f2144f244d1bf8e67e55457f8eb
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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