Acetic Anhydride → HCID 19375072, compound

HRID 128801

Reaction equation

HRID 128801 reaction equation
[CH3:1][CH:2]([C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([CH:13]([CH3:15])[CH3:14])[C:11]=1[OH:12])[CH:7]=[O:8])[CH3:3].[C:16](OC(=O)C)(=[O:18])[CH3:17]>CN(C1C=CN=CC=1)C.ClCCCl>[C:16]([O:12][C:11]1[C:10]([CH:13]([CH3:15])[CH3:14])=[CH:9][C:6]([CH:7]=[O:8])=[CH:5][C:4]=1[CH:2]([CH3:1])[CH3:3])(=[O:18])[CH3:17]

Participants

5

Reactant 2

HCID 7918Acetic AnhydrideHCID 827124-Hydroxy-3,5-bis(isopropyl)benzaldehyde

Product 1

HCID 19375072HCID 19375072, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 111,2-DichloroethaneSolvent

Procedure

3,5-bis(1-methylethyl)-4-hydroxybenzaldehyde is acetylated with acetic anhydride in refluxing 1,2-dichloroethane, in the presence of DMAP, to provide 4-acetoxy-3,5-Bis(1-methylethyl)benzaldehyde. This material is converted by the method of example 2 into the title compound, obtained as a white solid, mp 95°-97° after recrystallization from hexane.

Sources & evidence

ORD record
ord-e473a5f3f5384d65b69756244cd94348
Source dataset
uspto-grants-1995_11
Patent number
US05464865

Linked notes

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